Mushrooms may help reduce anti-ageing

'You can see that countries that have more ergothioneine in their diets have lower incidences of neurodegenerative diseases'.

Mushrooms may help fight ageing and age-related diseases, scientists say.

Mushrooms contain “unusually” high amounts of antioxidants–ergothioneine and glutathione, said Robert Beelman, Professor Emeritus at Pennsylvania State University in the US in a new study.

“What we found is that, without a doubt, mushrooms are highest dietary source of these two antioxidants taken together, and that some types are really packed with both of them,” Beelman said, adding that when the body uses food to produce energy, it causes oxidative stress as it produces some free radicals.

The study published in the journal Food Chemistry suggests that the amounts of ergothioneine and glutathione in mushrooms vary by species with the porcini species, a wild variety, containing the highest amount of the two compounds among the 13 species tested.

“We found that the porcini has the highest, by far, of any we tested,” said Beelman. “This species is really popular in Italy where searching for it has become a national pastime.”

The more common mushroom types, like the white button, had less of the antioxidants, but had higher amounts than most other foods, Beelman said.

Free radicals are oxygen atoms with unpaired electrons that cause damage to cells, proteins and even DNA as these highly reactive atoms travel through the body seeking to pair up with other electrons.

“There’s a theory — the free radical theory of aging — that’s been around for a long time that says when we oxidize our food to produce energy there’s a number of free radicals that are produced that are side products of that action and many of these are quite toxic,” Beelman said.

Replenishing antioxidants in the body, then, may help protect against this oxidative stress.

The amount of ergothioneine and glutathione appear to be correlated in mushrooms, the researchers said.

Mushrooms that are high in glutathione are also high in ergothioneine, for example.

Cooking mushrooms does not seem to significantly affect the compounds, Beelman said.

The researchers said that future research may look at any role that ergothioneine and glutathione have in decreasing the likelihood of neurodegenerative diseases, such as Parkinson’s disease and Alzheimer’s disease.

“It’s preliminary, but you can see that countries that have more ergothioneine in their diets, countries like France and Italy, also have lower incidences of neurodegenerative diseases, while people in countries like the United States, which has low amounts of ergothioneine in the diet, have a higher probability of diseases like Parkinson’s Disease and Alzheimer’s,” Beelman said.